Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904684 | 0.90 | RAB9A (0.39) | SMN1; SMN2HRH3KDM4EHDAC1HDAC2 | |
| SCHEMBL7896508 | 0.81 | HRH3 (0.41) | HRH3KDM4EBACE1 | |
| SCHEMBL7905735 | 0.80 | HRH3 (0.38) | SMN1; SMN2HRH3KDM4ENOTUMHDAC1 | |
| SCHEMBL7903943 | 0.79 | QPCT (0.42) | SMN1; SMN2HRH3KDM4EHDAC1HDAC2 | |
| SCHEMBL7905860 | 0.78 | RAB9A (0.35) | SMN1; SMN2HRH3KDM4EHDAC1HDAC2 | |
| SCHEMBL7905780 | 0.77 | HRH3 (0.40) | HRH3KDM4EBACE1 | |
| SCHEMBL7908470 | 0.77 | HRH3 (0.44) | SMN1; SMN2HRH3KDM4E | |
| SCHEMBL7903925 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2HRH3KDM4ENOTUMHDAC1 | |
| SCHEMBL7896504 | 0.76 | HRH3 (0.39) | HRH3KDM4EBACE1 | |
| SCHEMBL7896445 | 0.76 | KDM4E (0.34) | SMN1; SMN2HRH3KDM4EBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |