Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | RXRB | P28702 | 4/20 | 0.41 |
| ▸ | RXRG | P48443 | 4/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.38 |
| ▸ | FNTB | P49356 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903902 | 0.90 | RAB9A (0.40) | RXRARXRBRXRGFFAR1FFAR4 | |
| SCHEMBL7910209 | 0.77 | FNTA (0.41) | FFAR1FFAR4FNTAFNTBS1PR1 | |
| SCHEMBL7905174 | 0.75 | PPARG (0.40) | FFAR1FFAR4FNTAFNTBS1PR1 | |
| SCHEMBL29288338 | 0.73 | NR1H4 (0.47) | RXRARXRBRXRGS1PR1 | |
| SCHEMBL6673753 | 0.72 | BACE1 (0.49) | — | |
| SCHEMBL31094071 | 0.72 | BACE1 (0.49) | — | |
| SCHEMBL7904816 | 0.71 | FFAR1 (0.42) | FFAR1FFAR4FNTAFNTBMCL1 | |
| SCHEMBL6771653 | 0.71 | FNTA (0.66) | FNTAFNTB | |
| SCHEMBL2853361 | 0.71 | ALDH1A1 (0.38) | RXRARXRBRXRG | |
| SCHEMBL22227467 | 0.70 | BRS3 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |