Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | VDR | P11473 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.38 |
| ▸ | FNTA | P49354 | 4/20 | 0.37 |
| ▸ | FNTB | P49356 | 4/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7903908 | 0.90 | RXRA (0.41) | FFAR4FNTAFNTBRXRARXRB | |
| SCHEMBL7905904 | 0.78 | FNTA (0.43) | MAPTFNTAFNTBKDM4EHPGD | |
| SCHEMBL7910498 | 0.76 | FNTA (0.42) | FFAR4FNTAFNTBFFAR1 | |
| SCHEMBL8128802 | 0.73 | KDM4E (0.44) | RAB9ALMNAMAPTFFAR4KDM4E | |
| SCHEMBL25591913 | 0.73 | ALDH1A1 (0.50) | RAB9ALMNABACE1KDM4ENPC1 | |
| SCHEMBL7910206 | 0.72 | FNTA (0.43) | FFAR4FNTAFNTBFFAR1 | |
| SCHEMBL6776213 | 0.72 | FNTA (0.64) | FNTAFNTB | |
| SCHEMBL6472720 | 0.72 | KDM4E (0.43) | RAB9AMAPTFFAR4BACE1KDM4E | |
| SCHEMBL628630 | 0.72 | LOXL2 (0.50) | LMNAMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL6624770 | 0.72 | SLC6A3 (0.46) | LMNAMAPTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |