Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CPN1 | P15169 | 1/20 | 0.40 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18500640 | 0.81 | PBRM1 (0.50) | PBRM1ADRB2ADRB1ADRB3NPC1 | |
| SCHEMBL9461011 | 0.79 | NPC1 (0.50) | NPC1POLBLMNAALDH1A1KDM4E | |
| SCHEMBL7914192 | 0.79 | CA2 (0.51) | — | |
| SCHEMBL13464256 | 0.79 | ALDH1A1 (0.47) | PBRM1ADRB2ADRB1ADRB3NPC1 | |
| SCHEMBL28194722 | 0.78 | PBRM1 (0.50) | PBRM1ADRB2ADRB1ADRB3NPC1 | |
| SCHEMBL6943712 | 0.77 | PRSS1 (0.46) | LMNAPRSS1PRSS2PRSS3 | |
| SCHEMBL7912220 | 0.76 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL2208370 | 0.75 | PBRM1 (0.55) | PBRM1ADRB2ADRB1ADRB3NPC1 | |
| SCHEMBL28359889 | 0.75 | PBRM1 (0.59) | PBRM1ADRB2ADRB1ADRB3NPC1 | |
| SCHEMBL8930000 | 0.75 | ELANE (0.56) | PBRM1ADRB2ADRB1ADRB3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214882-B1 | Benzenesulphonamide derivatives, preparation thereof and therapeutical uses thereof | SYNTHELABO (FR) | 2001-04-10 | — | — | US | disclosed |
| EP-0842148-B1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SANOFI SYNTHELABO (FR) | 2000-12-20 | — | — | EP | disclosed |
| EP-0842148-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997006136-A1 | BENZENESULPHONAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USES THEREOF | SYNTHELABO (FR) | 1997-02-20 | — | — | WO | disclosed |