Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6949247 | 0.82 | LTA4H (0.43) | MCHR1LMNAMAPK1CASP3SENP7 | |
| SCHEMBL9461011 | 0.82 | NPC1 (0.50) | LMNAPTPN1MAPK1L3MBTL1TSHR | |
| SCHEMBL27639484 | 0.78 | PRSS1 (0.45) | PRSS1PRSS2PRSS3LMNAPTPN1 | |
| SCHEMBL7904031 | 0.77 | PBRM1 (0.46) | PRSS1PRSS2PRSS3LMNA | |
| SCHEMBL8581011 | 0.75 | L3MBTL1 (0.53) | PRSS1PRSS2PRSS3LMNAPTPN1 | |
| SCHEMBL2379457 | 0.74 | TRPA1 (0.62) | PRSS1PRSS2PRSS3LMNAPTPN1 | |
| SCHEMBL6492538 | 0.74 | PTPN1 (0.62) | PRSS1PRSS2PRSS3LMNAPTPN1 | |
| SCHEMBL6190226 | 0.74 | LMNA (0.69) | PRSS1PRSS2PRSS3LMNACA1 | |
| SCHEMBL1926951 | 0.73 | FOLH1 (0.66) | PRSS1PRSS2PRSS3CA1CA2 | |
| SCHEMBL6949804 | 0.73 | PSMB5 (0.45) | PRSS1PRSS2PRSS3LMNAPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082121-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2003-02-05 | — | — | EP | disclosed |
| US-6380249-B1 | HIV integrase inhibitors | MERCK & CO., INC. | 2002-04-30 | — | — | US | disclosed |
| EP-1082121-A1 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2001-03-14 | — | — | EP | disclosed |
| WO-1999062520-A1 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 1999-12-09 | — | — | WO | disclosed |