Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.39 |
| ▸ | PI4KA | P42356 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789984 | 0.81 | PI4KA (0.47) | PIK3CAPIK3CGPI4KAPIK3R1 | |
| SCHEMBL791169 | 0.80 | PIK3CG (0.47) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL790456 | 0.79 | PIK3CA (0.46) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL789648 | 0.78 | PIK3CA (0.67) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL790993 | 0.78 | PIK3CG (0.67) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL806992 | 0.72 | PIK3CG (0.73) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL789700 | 0.69 | PIK3CG (0.45) | PIK3CAPIK3CGPI4KAPIK3CDPIK3R1 | |
| SCHEMBL789481 | 0.69 | PI4KA (0.45) | PIK3CGPI4KAJAK2JAK1TYK2 | |
| SCHEMBL789602 | 0.68 | PI4KA (0.41) | PIK3CGPI4KAJAK2JAK1TYK2 | |
| SCHEMBL807103 | 0.67 | PI4KA (0.76) | PIK3CAPIK3CGPI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |