Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 5/20 | 0.38 |
| ▸ | NOS1 | P29475 | 5/20 | 0.38 |
| ▸ | NOS2 | P35228 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR1B | P28222 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902674 | 0.96 | HRH3 (0.40) | HRH3HTR7NOS3NOS1NOS2 | |
| SCHEMBL7904622 | 0.95 | HRH3 (0.39) | HRH3HTR7NOS3NOS1NOS2 | |
| SCHEMBL7896508 | 0.88 | HRH3 (0.41) | HRH3KDM4EALDH1A1PTPN11 | |
| SCHEMBL7905780 | 0.87 | HRH3 (0.40) | HRH3KDM4EALDH1A1PTPN11 | |
| SCHEMBL7902706 | 0.87 | HRH3 (0.38) | HRH3KDM4EALDH1A1HTR1B | |
| SCHEMBL7904665 | 0.87 | HRH3 (0.36) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7908481 | 0.87 | PIK3CB (0.44) | HRH3KDM4EPIK3CDPIK3R1PIK3CA | |
| SCHEMBL7896504 | 0.86 | HRH3 (0.39) | HRH3HTR7KDM4EALDH1A1PTPN11 | |
| SCHEMBL7896424 | 0.83 | ALDH1A1 (0.42) | HRH3KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7896433 | 0.82 | POLB (0.38) | KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191152-B1 | CARDIOVASCULAR DISORDERS, NERVOUS SYSTEM DISORDERS | EGIS GYÓGYSZERGYAR RT. (HU) | 2001-02-20 | — | — | US | disclosed |