Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BUB1 | O43683 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CCKAR | P32238 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905830 | 0.79 | SIRT2 (0.48) | HDAC1HDAC2HDAC3MEN1POLB | |
| SCHEMBL7915451 | 0.78 | CNR1 (0.46) | BUB1KCNH2PRMT6MEN1POLB | |
| SCHEMBL7913081 | 0.77 | HDAC3 (0.46) | BUB1PRMT6HDAC1HDAC2HDAC3 | |
| SCHEMBL7905887 | 0.76 | APP (0.50) | HDAC2 | |
| SCHEMBL7915476 | 0.73 | CNR1 (0.45) | BUB1HDAC1HDAC2HDAC3MEN1 | |
| SCHEMBL7914160 | 0.72 | CXCR2 (0.43) | HDAC1MEN1POLBKMT2A | |
| SCHEMBL7905484 | 0.72 | MEN1 (0.50) | PRMT6HDAC1MEN1KMT2A | |
| SCHEMBL7916081 | 0.71 | CNR1 (0.47) | — | |
| SCHEMBL17664060 | 0.71 | MAPT (0.45) | MEN1POLBKMT2A | |
| SCHEMBL7091792 | 0.71 | RAPGEF4 (0.51) | BUB1MEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6211220-B1 | ANTITUMOR AGENTS AND ANTICARCIINOGENIC AGENTS | CELL PATHWAYS, INC. | 2001-04-03 | — | — | US | claimed |
| WO-1994029277-A1 | AMILINO- OR PYRIDYLAMINO- CYCLOBUTENE- 1,2-DIONE DERIVATIVES AS cGMP PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-22 | — | — | WO | claimed |
| US-6211220-B1 | ANTITUMOR AGENTS AND ANTICARCIINOGENIC AGENTS | CELL PATHWAYS, INC. | 2001-04-03 | — | — | US | disclosed |
| WO-1994029277-A1 | AMILINO- OR PYRIDYLAMINO- CYCLOBUTENE- 1,2-DIONE DERIVATIVES AS cGMP PHOSPHODIESTERASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1994-12-22 | — | — | WO | disclosed |