Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.34 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL790927 | 0.84 | APP (0.37) | EGFRAPPGAAMAPT | |
| SCHEMBL10277683 | 0.80 | SIK1 (0.39) | KDM4EALDH1A1HPGDAPPMEN1 | |
| SCHEMBL790759 | 0.73 | KDM4E (0.47) | ADORA1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL1414662 | 0.66 | ADORA1 (0.39) | ADORA1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL790933 | 0.66 | APP (0.47) | ADORA2AKDM4EALDH1A1HPGDDHFR | |
| SCHEMBL790839 | 0.65 | ADORA2A (0.49) | ADORA1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL7913439 | 0.65 | KDM4E (0.60) | ADORA1ADORA2AEGFRKDM4EALDH1A1 | |
| SCHEMBL6223729 | 0.64 | ALDH1A1 (0.67) | ADORA1ADORA2AKDM4EALDH1A1HPGD | |
| SCHEMBL27576309 | 0.64 | ADORA1 (0.55) | ADORA1ADORA2AEGFRERBB2KDM4E | |
| SCHEMBL27470171 | 0.61 | ADORA2A (0.58) | ADORA1ADORA2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |