Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | DHPS | P49366 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL789402 | 0.78 | CYP1A2 (0.41) | HPGDPOLBCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL789718 | 0.78 | CYP1A1 (0.41) | APPCYP1A2CYP1A1CYP1B1KDM4E | |
| SCHEMBL790753 | 0.76 | CYP1A2 (0.37) | APPCYP1A2CYP1A1CYP1B1KDM4E | |
| SCHEMBL790609 | 0.75 | LMNA (0.48) | LMNA | |
| SCHEMBL790759 | 0.75 | KDM4E (0.47) | PIK3CDPIK3CAPIK3CBPIK3CGHPGD | |
| SCHEMBL29534215 | 0.73 | KMT2A (0.54) | LMNASMN1; SMN2POLBKDM4EMAPT | |
| SCHEMBL22919474 | 0.73 | KMT2A (0.54) | LMNASMN1; SMN2POLBKDM4EMAPT | |
| SCHEMBL27556561 | 0.70 | CYP1A1 (0.69) | HPGDPOLBCYP1A2CYP1A1CYP1B1 | |
| SCHEMBL28041569 | 0.69 | SLC10A2 (0.56) | APPHPGDLMNASMN1; SMN2POLB | |
| SCHEMBL29058866 | 0.69 | ESR1 (0.64) | HPGDLMNASMN1; SMN2POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |
| WO-2012037108-A1 | AMINOQUINOLINE DERIVATIVES AS ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2012-03-22 | — | — | WO | disclosed |