Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364030 | 0.88 | LMNA (0.60) | LMNATP53MEN1KMT2AADORA2A | |
| SCHEMBL741775 | 0.88 | LMNA (0.78) | LMNATP53ADORA2AADORA2BHPGD | |
| SCHEMBL741776 | 0.88 | LMNA (0.78) | LMNATP53ADORA2AADORA2BHPGD | |
| SCHEMBL8626875 | 0.87 | ADORA2A (0.64) | LMNAADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL26646355 | 0.87 | ADORA2A (0.64) | LMNAADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL9413285 | 0.85 | ADORA3 (0.62) | MEN1KMT2AADORA2AADORA2BADORA3 | |
| SCHEMBL6635214 | 0.85 | MEN1 (0.65) | LMNATP53MEN1KMT2AADORA2A | |
| SCHEMBL20724423 | 0.85 | PDE2A (0.67) | LMNATP53ADORA2AADORA2BHPGD | |
| SCHEMBL1796936 | 0.85 | MEN1 (0.65) | LMNATP53MEN1KMT2AADORA2A | |
| SCHEMBL8904692 | 0.83 | LMNA (0.61) | LMNATP53MEN1KMT2AADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE37077-E1 | Adenosine derivatives and pharmaceutical composition thereof | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-0378518-B1 | Adenosine derivatives having pharmaceutical activity as antihypertensives | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 1994-09-28 | — | — | EP | disclosed |
| US-4985409-A | HYPOTENSIVE AGENTS | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-15 | — | — | US | disclosed |