Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905938 | 0.81 | ALOX5AP (0.37) | GPR119SCN9AHPGDSMEN1ALDH1A1 | |
| SCHEMBL7906017 | 0.76 | HPGDS (0.42) | GPR119JAK2JAK1HPGDSMEN1 | |
| SCHEMBL7898507 | 0.73 | KAT7 (0.39) | GPR119SCN9AJAK2JAK1MEN1 | |
| SCHEMBL2792044 | 0.72 | JAK2 (0.45) | SCN9AMMP1MMP9MMP13JAK2 | |
| SCHEMBL2792042 | 0.72 | JAK2 (0.45) | SCN9AMMP1MMP9MMP13JAK2 | |
| SCHEMBL25345014 | 0.69 | PRMT5 (0.46) | GPR119SCN9AJAK2JAK1HPGDS | |
| SCHEMBL27211093 | 0.69 | PRMT5 (0.46) | GPR119SCN9AJAK2JAK1HPGDS | |
| SCHEMBL30473704 | 0.69 | PRMT5 (0.46) | GPR119SCN9AJAK2JAK1HPGDS | |
| SCHEMBL22441487 | 0.69 | NCF1 (0.49) | GPR119PIK3CA | |
| SCHEMBL22445616 | 0.69 | NCF1 (0.49) | GPR119PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010111634-A2 | RENIN INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-30 | — | — | WO | disclosed |