Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL17003962 | 0.91 | HPGD (0.39) | HPGDLMNAALDH1A1CYP2C19KDM4E | |
| Acetic Acid SCHEMBL7939756 | 0.87 | ALPL (0.41) | HPGDLMNAALDH1A1CYP2C19CYP3A4 | |
| Hydrochloric Acid SCHEMBL58307 | 0.86 | CYP1A2 (0.36) | HPGDLMNAALDH1A1CYP2C19KDM4E | |
| Methacrylic Acid SCHEMBL7050319 | 0.86 | CHRM1 (0.36) | HPGDCYP2C19CHRM2CHRM4CHRM1 | |
| Methacrylic Acid SCHEMBL591806 | 0.86 | ALPL (0.37) | HPGDLMNAALDH1A1CYP2C19KDM4E | |
| Bicarbonate SCHEMBL9180912 | 0.85 | ALPL (0.42) | HPGDLMNACYP2C19CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL9501111 | 0.84 | CYP1A2 (0.35) | HPGDLMNAALDH1A1CYP2C19KDM4E | |
| SCHEMBL210755 | 0.84 | CYP1A2 (0.37) | HPGDLMNAALDH1A1CYP2C19KDM4E | |
| Acrylamide SCHEMBL11702078 | 0.84 | LMNA (0.37) | HPGDLMNAALDH1A1CYP2C19CHRM2 | |
| Acrylic Acid SCHEMBL10610466 | 0.83 | ALPL (0.38) | HPGDLMNAALDH1A1CYP2C19CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197843-B1 | Method for preparing ceramic articles | THE DOW CHEMICAL COMPANY | 2001-03-06 | — | — | US | disclosed |