Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 5/20 | 0.36 |
| ▸ | CHRM3 known ✓ | P20309 | 5/20 | 0.36 |
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL5841775 | 0.94 | CHRM4 (0.33) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Methacrylic Acid SCHEMBL7906126 | 0.86 | HPGD (0.41) | CHRM1CHRM3CHRM4CHRM2POLB | |
| SCHEMBL10883968 | 0.81 | CHRM1 (0.45) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Methacrylic Acid SCHEMBL591806 | 0.81 | ALPL (0.37) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Styrene SCHEMBL11315893 | 0.81 | TSHR (0.42) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Ethylene Glycol SCHEMBL4653120 | 0.79 | TRPA1 (0.38) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Styrene SCHEMBL28447649 | 0.78 | TDP1 (0.41) | POLBAPEX1HTTTDP1CA1 | |
| Methacrylic Acid SCHEMBL17003962 | 0.78 | HPGD (0.39) | CHRM1CHRM3CHRM4CHRM2POLB | |
| Hydrochloric Acid SCHEMBL9550685 | 0.77 | CHRM1 (0.43) | CHRM1CHRM3CHRM4CHRM2POLB | |
| SCHEMBL10596683 | 0.77 | CHRM1 (0.43) | CHRM1CHRM3CHRM4CHRM2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0864625-B1 | Antistatic composition and photographic element containing a layer of this composition | EASTMAN KODAK CO (US) | 2003-04-16 | — | — | EP | disclosed |
| US-5910400-A | HOMOGENEOUS AQUEOUS FILM FORMING COMPOSITION CONTAINING A LATEX | EASTMAN KODAK COMPANY (US) | 1999-06-08 | — | — | US | disclosed |
| EP-0864625-A1 | Antistatic composition and photographic element containing a layer of this composition | EASTMAN KODAK COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |