Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | RPS27 | P42677 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2871462 | 0.90 | ALDH1A1 (0.40) | KDM4EALDH1A1PDE10APOLBMAPT | |
| SCHEMBL7913445 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1SQORPDE10ARPS27 | |
| SCHEMBL7916437 | 0.78 | ALDH1A1 (0.38) | KDM4EALDH1A1PDE10AKMT2AMEN1 | |
| SCHEMBL7906146 | 0.78 | SQOR (0.47) | KDM4EALDH1A1SQORPDE10ARPS27 | |
| SCHEMBL7916401 | 0.76 | ADORA2A (0.43) | KDM4EALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL4960133 | 0.73 | SQOR (0.43) | KDM4EALDH1A1SQORPDE10ARPS27 | |
| SCHEMBL7914416 | 0.72 | ALDH1A1 (0.40) | KDM4EALDH1A1POLBMAPTNPSR1 | |
| SCHEMBL7914406 | 0.72 | CYP1A2 (0.38) | KDM4EALDH1A1KMT2AMEN1POLB | |
| SCHEMBL3349292 | 0.71 | POLB (0.61) | KDM4EALDH1A1KMT2AMEN1ELANE | |
| SCHEMBL29488275 | 0.71 | POLB (0.61) | KDM4EALDH1A1KMT2AMEN1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297258-B1 | USEFUL AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYSTIC KIDNEY DISEASE. | AMERICAN CYANAMID COMPANY | 2001-10-02 | — | — | US | disclosed |
| US-6288082-B1 | COMPOUNDS SUCH AS 6,7-DIETHOXY-4-(INDAN-5-YLAMINO) -QUINOLINE-3-CARBONITRILE USED AS ANTINEOPLASTIC AGENTS AND IN THE TREATMENT OF POLYCYCSTIC KIDNEY DISEASE | AMERICAN CYANAMID COMPANY | 2001-09-11 | — | — | US | disclosed |