Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.44 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.73 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.73 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.73 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | FNTA | P49354 | 1/20 | 0.45 |
| ▸ | FNTB | P49356 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 6/20 | 0.44 |
| ▸ | PPARD | Q03181 | 6/20 | 0.44 |
| ▸ | PPARA | Q07869 | 6/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL31552907 | 1.00 | GPR84 (0.73) | GPR84FFAR1FFAR4CAMK2AABCC4 | |
| Adipic Acid SCHEMBL8593870 | 1.00 | GPR84 (0.73) | GPR84FFAR1FFAR4CAMK2AABCC4 | |
| Octanedioate SCHEMBL31348984 | 0.91 | TSHR (0.67) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Azelaic Acid SCHEMBL31688973 | 0.91 | TSHR (0.67) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Sebacic Acid SCHEMBL2776922 | 0.91 | TSHR (0.67) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Sebacic Acid SCHEMBL30655949 | 0.91 | TSHR (0.67) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Adipic Acid SCHEMBL3293975 | 0.88 | LMNA (0.65) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Adipic Acid SCHEMBL29532685 | 0.88 | LMNA (0.65) | GPR84FFAR1FFAR4ABCC4MAPT | |
| Acrylic Acid SCHEMBL25361515 | 0.88 | LMNA (0.59) | GPR84FFAR1FFAR4CAMK2AABCC4 | |
| Acrylic Acid SCHEMBL8852419 | 0.88 | LMNA (0.59) | GPR84FFAR1FFAR4CAMK2AABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197723-B1 | USEFUL FOR BLOCK COPY FOR FLEXOGRAPHY, GRAVURE PRINTING, OFFSET PRINTING AND SCREEN PRINTING | RICOH COMPANY LTD. (JP) | 2001-03-06 | — | — | US | disclosed |
| EP-0566353-B1 | Photopolymerizable composition | MITSUBISHI RAYON CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| EP-0566353-A1 | Photopolymerizable composition | MITSUBISHI RAYON COMPANY LTD. (JP) | 1993-10-20 | — | — | EP | disclosed |