Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 15/20 | 0.72 |
| ▸ | ALPL | P05186 | 1/20 | 0.69 |
| ▸ | ALPI | P09923 | 1/20 | 0.69 |
| ▸ | ALPG | P10696 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5361880 | 0.85 | HDAC1 (0.74) | GAAALPLALPIALPGCYP2C9 | |
| SCHEMBL8723753 | 0.84 | GAA (0.69) | GAAALPLALPIALPGCYP2C9 | |
| SCHEMBL2988299 | 0.82 | HDAC1 (0.65) | GAAALPLALPIALPGCYP2C9 | |
| Nicotinyl Methylamide SCHEMBL28560459 | 0.81 | HDAC1 (0.69) | GAAALPLALPIALPGALDH1A1 | |
| Nicotinyl Methylamide SCHEMBL30664356 | 0.81 | HDAC1 (0.69) | GAAALPLALPIALPGALDH1A1 | |
| Nicotinyl Methylamide SCHEMBL129458 | 0.81 | HDAC1 (0.69) | GAAALPLALPIALPGALDH1A1 | |
| SCHEMBL255625 | 0.81 | CA1 (0.65) | GAAALPLALPIALPGCYP2C9 | |
| Iodide SCHEMBL28221159 | 0.80 | HDAC1 (0.62) | GAAALPLALPIALPGCYP2C9 | |
| SCHEMBL2477798 | 0.80 | GAA (0.69) | GAAALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL18136525 | 0.80 | KMT2A (0.63) | GAAALPLALPIALPGCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110306768-A1 | PROCESSES FOR THE MANUFACTURE OF 3--PYRIDINE, 4-METHYL-3-METHYLTHIO-5-(3-PYRIDYL)-L,2,4-TRIAZOLE, AND (1R)-1-[2-(3-METHYLPHENYL)-2H-TETRAZOL-5-YL]ETHANOL | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | US | disclosed |
| WO-2010071559-A1 | PROCESSES FOR THE MANUFACTURE OF 3-{4-METHYL-5- [ (IR) -1- (2- (3-METHYLPHENYL) -2H-TETRAZOL-5-YL) -ETHOXY] -4H- [1,2, 4] TRIAZOL-3-YL} -PYRIDINE, 4-METHYL-3-METHYLTHIO-5- (3- PYRIDYL)-L,2,4-TRIAZOLE, AND (IR) -1- [2- (3-METHYLPHENYL) -2H- TETRAZOL-5-YL] ETHANOL | ASTRAZENECA AB (SE) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306768-A1 | PROCESSES FOR THE MANUFACTURE OF 3--PYRIDINE, 4-METHYL-3-METHYLTHIO-5-(3-PYRIDYL)-L,2,4-TRIAZOLE, AND (1R)-1-[2-(3-METHYLPHENYL)-2H-TETRAZOL-5-YL]ETHANOL | ADH1A, ADH5, ADH1C | GAA 4307/4885ALPL 1258/4885ALPI 2963/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.