Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | MITF | O75030 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 4/20 | 0.54 |
| ▸ | CA2 | P00918 | 4/20 | 0.54 |
| ▸ | CA9 | Q16790 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29836775 | 0.88 | LOXL2 (0.61) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL134170 | 0.88 | LOXL2 (0.61) | PBRM1NPC1MITFLMNAPOLB | |
| Hydrochloric Acid SCHEMBL2477797 | 0.86 | LOXL2 (0.59) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL2339850 | 0.86 | TSHR (0.61) | NPC1POLBCA1CA2CA9 | |
| SCHEMBL203373 | 0.86 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL9097509 | 0.86 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL29492473 | 0.86 | PBRM1 (0.88) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL7898874 | 0.84 | TSHR (0.50) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL6797504 | 0.83 | PBRM1 (0.66) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL7908252 | 0.82 | CA1 (0.57) | LMNACA1CA2CA9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1083888-A1 | MULTIBINDING AGENTS THAT MODULATE PPARgamma AND RXR RECEPTORS | Advanced Medicine, Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999063983-A9 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE INC (US) | 2000-03-23 | — | — | WO | disclosed |
| WO-1999063983-A1 | MULTIBINDING AGENTS THAT MODULATE PPARη AND RXR RECEPTORS | ADVANCED MEDICINE, INC. (US) | 1999-12-16 | — | — | WO | disclosed |