Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475632 | 0.88 | GLA (0.53) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL7475644 | 0.88 | GLA (0.53) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL31530473 | 0.86 | ALDH1A1 (0.59) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL31530477 | 0.86 | ALDH1A1 (0.59) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL5248182 | 0.79 | SLC6A2 (0.58) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL308242 | 0.79 | TSHR (0.53) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL7908196 | 0.77 | SMN1; SMN2 (0.55) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL7904464 | 0.77 | ALDH1A1 (0.49) | ALDH1A1CYP3A4TSHRHTTKCNMA1 | |
| SCHEMBL7904396 | 0.75 | CTSD (0.47) | GLASMN1; SMN2ALDH1A1CYP1A2POLB | |
| SCHEMBL631453 | 0.75 | ALDH1A1 (0.57) | ALDH1A1CYP1A2CYP3A4CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6201119-B1 | 2,3,4,5-TETRAHYDRO-1H-1,4-BENZODIAZEPIN-9-AMINE COMPOUNDS USEFUL AS INTERMEDIATES TO ANTIVIRALS | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-03-13 | — | — | US | disclosed |
| CN-1034122-C | Antiviral tetrahydroimioazo [1,4] benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA NV (BE) | 1997-02-26 | — | — | CN | disclosed |
| CN-1031058-C | Antiviral tetrahydroimidazo [1,4]-benzodiazepin-2-ones | JANSSEN PHARMACEUTICA NV (BE) | 1996-02-21 | — | — | CN | disclosed |
| CN-1029848-C | Process for preparing tetrahydroimidazo [1,4] benzodiazepin-2-thiones | JANSSEN PHARMACEUTICA NV (BE) | 1995-09-27 | — | — | CN | disclosed |
| CN-1057840-A | New antiviral imidazolidine is [1,4] benzodiazepine-2-(sulphur) ketone also | JANSSEN PHARMACEUTICA NV (BE) | 1992-01-15 | — | — | CN | disclosed |
| CN-1045105-A | Imidazolidine is the preparation method of [1,4] benzodiazepine-2-thioketones also | JANSSEN PHARMACEUTICA NV (BE) | 1990-09-05 | — | — | CN | disclosed |
| CN-1036957-A | It is antiviral with imidazolidine [1,4] benzodiazepine-2-ketone compounds also, | JANSSEN PHARMACEUTICA NV (BE) | 1989-11-08 | — | — | CN | disclosed |