Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7475632 | 1.00 | GLA (0.53) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7908193 | 0.88 | GLA (0.55) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL513385 | 0.86 | ALDH1A1 (0.61) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7908196 | 0.83 | SMN1; SMN2 (0.55) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15610552 | 0.81 | TDP1 (0.51) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15610652 | 0.81 | TDP1 (0.51) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL15610551 | 0.81 | TDP1 (0.51) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL5248182 | 0.80 | SLC6A2 (0.58) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7908199 | 0.77 | TSHR (0.47) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL7904396 | 0.76 | CTSD (0.47) | GLASMN1; SMN2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538297-B9 | ANTIVIRAL TETRAHYDROIMIDAZO 1,4]BENZODIAZEPIN-2-(THIO)ONES | JANSSEN PHARMACEUTICA NV (BE) | 2002-10-16 | — | — | EP | disclosed |
| EP-0538297-B1 | ANTIVIRAL TETRAHYDROIMIDAZO 1,4]BENZODIAZEPIN-2-(THIO)ONES | JANSSEN PHARMACEUTICA NV (BE) | 2001-09-19 | — | — | EP | disclosed |
| US-5371079-A | Administering to inhibit replication of HIV-1 in human cells | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-12-06 | — | — | US | disclosed |
| US-5270464-A | Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-12-14 | — | — | US | disclosed |
| EP-0384522-B1 | Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-13 | — | — | EP | disclosed |
| EP-0336466-B1 | ANTIVIRAL TETRAHYDROIMIDAZO (1,4) BENZODIAZEPIN-2-ONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-30 | — | — | EP | disclosed |
| WO-1992000979-A1 | ANTIVIRAL TETRAHYDROIMIDAZO[1,4]BENZODIAZEPIN-2-(THIO)ONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-01-23 | — | — | WO | disclosed |
| EP-0384522-A1 | Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-29 | — | — | EP | disclosed |
| EP-0336466-A1 | Antiviral tetrahydroimidazo (1,4) benzodiazepin-2-ones | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-10-11 | — | — | EP | disclosed |