Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | BRS3 | P32247 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.33 |
| ▸ | GABRE | P78334 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27334880 | 0.91 | ALDH1A1 (0.35) | ALDH1A1MAPK1HCAR2 | |
| SCHEMBL27431049 | 0.87 | GPR84 (0.36) | PARP1GPR84ALDH1A1MAPK1GSK3B | |
| SCHEMBL7300673 | 0.83 | CYP1A2 (0.42) | GPR84ALDH1A1MAPK1 | |
| SCHEMBL27352613 | 0.80 | GLA (0.34) | GPR84ALDH1A1MAPK1HCAR2 | |
| SCHEMBL7300490 | 0.78 | HCAR2 (0.44) | PARP1GPR84ALDH1A1MAPK1HCAR2 | |
| SCHEMBL4846607 | 0.77 | KDM5B (0.33) | ALDH1A1MAPK1HCAR2 | |
| SCHEMBL3038066 | 0.76 | PARP1 (0.41) | PARP1GPR84ALDH1A1MAPK1HCAR2 | |
| SCHEMBL7914214 | 0.75 | PARP1 (0.40) | PARP1GPR84ALDH1A1MAPK1HCAR2 | |
| SCHEMBL27322051 | 0.75 | PARP1 (0.40) | PARP1GPR84ALDH1A1MAPK1HCAR2 | |
| SCHEMBL3839556 | 0.74 | PARP1 (0.39) | PARP1GPR84ALDH1A1MAPK1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545912-B1 | 1-Biphenylmethylimidazole derivatives, their preparation and their therapeutic use | SANKYO CO (JP) | 2001-04-25 | — | — | EP | disclosed |