Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | PRKACA | P17612 | 1/20 | 0.34 |
| ▸ | GRK5 | P34947 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6176307 | 0.81 | MMP2 (0.46) | MMP2MMP9CYP2D6LMNACHRNB2 | |
| SCHEMBL2842918 | 0.74 | CYP2D6 (0.44) | MMP2MMP9CYP2D6LMNAKDM4E | |
| SCHEMBL7593804 | 0.71 | ALOX5 (0.53) | CYP2D6KDM4EALOX5ALDH1A1MAPT | |
| SCHEMBL5949584 | 0.71 | ALOX5 (0.53) | CYP2D6KDM4EALOX5ALDH1A1MAPT | |
| SCHEMBL8319820 | 0.70 | HTR2A (0.46) | CYP2D6SMN1; SMN2LMNAKDM4EL3MBTL1 | |
| SCHEMBL11403653 | 0.70 | HTR2A (0.46) | CYP2D6SMN1; SMN2LMNAKDM4EL3MBTL1 | |
| SCHEMBL28294017 | 0.66 | CYP2D6 (0.39) | CYP2D6CYP2C19LMNAKDM4EL3MBTL1 | |
| SCHEMBL10010885 | 0.65 | TRPM8 (0.43) | CYP2D6SMN1; SMN2CYP2C19LMNACHRNB2 | |
| SCHEMBL12806730 | 0.64 | CYP2C19 (0.54) | CYP2D6SMN1; SMN2CYP2C19LMNAKDM4E | |
| SCHEMBL3258968 | 0.64 | TAAR1 (0.42) | CYP2C19LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6191150-B1 | METALLOPROTEASE INHIBITOR | GLAXO WELLCOME INC. | 2001-02-20 | — | — | US | disclosed |