Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908361 | 0.81 | MMP2 (0.43) | MMP2MMP9LMNAALDH1A1MAPT | |
| SCHEMBL10010885 | 0.81 | TRPM8 (0.43) | TRPM8LMNAALDH1A1MAPTAOC3 | |
| SCHEMBL1031859 | 0.78 | LMNA (0.52) | TRPM8LMNAAOC3POLBMEN1 | |
| SCHEMBL8576434 | 0.78 | LMNA (0.52) | TRPM8LMNAAOC3POLBMEN1 | |
| SCHEMBL1952126 | 0.76 | TRPM8 (0.49) | TRPM8LMNAALDH1A1AOC3POLB | |
| SCHEMBL7593804 | 0.75 | ALOX5 (0.53) | TRPM8ALDH1A1MAPTCYP2D6MEN1 | |
| SCHEMBL5949584 | 0.75 | ALOX5 (0.53) | TRPM8ALDH1A1MAPTCYP2D6MEN1 | |
| SCHEMBL2842918 | 0.74 | CYP2D6 (0.44) | MMP2MMP9LMNAALDH1A1CYP2D6 | |
| SCHEMBL11141579 | 0.73 | LMNA (0.47) | TRPM8LMNAALDH1A1MAPTAOC3 | |
| SCHEMBL29059910 | 0.72 | HTR2A (0.45) | TRPM8LMNAALDH1A1AOC3CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534281-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | Astrazeneca AB (SE) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004006925-A1 | N-SULFONYLPIPERIDINES AS METALLOPROTEINASE INHIBITORS (TACE) | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |