Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 8/20 | 0.38 |
| ▸ | MMP9 | P14780 | 8/20 | 0.38 |
| ▸ | MMP1 | P03956 | 7/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 7/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7905654 | 0.84 | CYP19A1 (0.53) | MMP2MMP9MMP1ADAM17CYP19A1 | |
| SCHEMBL7907214 | 0.77 | MMP2 (0.46) | MMP2MMP9POLBSMN1; SMN2KCNH2 | |
| SCHEMBL5926028 | 0.67 | MMP2 (0.42) | MMP2MMP9MMP1ADAM17POLB | |
| SCHEMBL22147753 | 0.66 | KMT2A (0.56) | MMP2MMP9MMP1ADAM17POLB | |
| SCHEMBL27524578 | 0.65 | OPRD1 (0.34) | — | |
| SCHEMBL16703117 | 0.65 | PER2 (0.39) | SMN1; SMN2 | |
| SCHEMBL6627912 | 0.65 | MMP2 (0.59) | MMP2MMP9MMP1ADAM17POLB | |
| SCHEMBL18408950 | 0.63 | ADRA1B (0.46) | CYP2D6HTR2CKCNH2 | |
| SCHEMBL17055197 | 0.63 | CYP19A1 (0.57) | MMP2MMP9MMP1ADAM17CYP19A1 | |
| SCHEMBL17055305 | 0.63 | CYP19A1 (0.57) | MMP2MMP9MMP1ADAM17CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6197975-B1 | 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS | MERCK & CO. , INC. | 2001-03-06 | — | — | US | disclosed |
| EP-0882040-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-02-10 | — | — | EP | disclosed |
| EP-0882040-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| WO-1997021707-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |