Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9231654 | 0.86 | — | — | |
| SCHEMBL1628330 | 0.81 | ALOX15 (0.52) | NCF1GNAO1GNAI3GNAI1PRMT3 | |
| Hydrochloric Acid SCHEMBL598320 | 0.79 | GNAO1 (0.54) | NCF1GNAO1GNAI3GNAI1PRMT3 | |
| SCHEMBL14890554 | 0.79 | NCF1 (0.56) | NCF1GNAO1GNAI3GNAI1PRMT3 | |
| SCHEMBL178287 | 0.79 | SMN1; SMN2 (0.46) | NCF1SMN1; SMN2ACHEHRH3 | |
| SCHEMBL2207870 | 0.78 | KEAP1 (0.47) | NCF1GNAO1GNAI3GNAI1SMN1; SMN2 | |
| Fluoride SCHEMBL29252276 | 0.77 | SMN1; SMN2 (0.45) | SMN1; SMN2ACHEHRH3 | |
| SCHEMBL8435896 | 0.76 | NCF1 (0.38) | NCF1GNAO1GNAI3GNAI1PRMT3 | |
| SCHEMBL23828683 | 0.75 | GNAO1 (0.46) | GNAO1GNAI3GNAI1HRH3 | |
| SCHEMBL772033 | 0.75 | NCF1 (0.36) | NCF1GNAO1SMN1; SMN2ACHEHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021194878-A1 | SELECTIVE MODULATORS OF MUTANT LRRK2 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-09-30 | — | — | WO | disclosed |
| WO-2010065743-A2 | BICYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME | NANOTHERAPEUTICS, INC. (US) | 2010-06-10 | — | — | WO | disclosed |