Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7544937 | 0.83 | CHAT (0.35) | SMN1; SMN2ALDH1A1AKR1C3MAPTKDM4E | |
| Iodide SCHEMBL3807575 | 0.82 | CHAT (0.37) | SMN1; SMN2ALDH1A1MEN1KMT2AAKR1C3 | |
| SCHEMBL2777625 | 0.78 | PTGS2 (0.44) | PTGS2HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL23220 | 0.76 | LMNA (0.46) | HTTLMNASMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL11386724 | 0.73 | RAB9A (0.51) | HTTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL11386719 | 0.73 | RAB9A (0.51) | HTTLMNASMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL18577930 | 0.71 | LMNA (0.49) | PTGS2HTTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL5762355 | 0.71 | LMNA (0.51) | HTTLMNASMN1; SMN2ALDH1A1CA12 | |
| SCHEMBL8466771 | 0.70 | PTGS2 (0.44) | PTGS2HTTLMNAALDH1A1CA12 | |
| SCHEMBL144101 | 0.70 | CA12 (0.39) | HTTLMNASMN1; SMN2ALDH1A1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6289027-B1 | Fiber optic lasers employing fiber optic amplifiers | MOLECULAR OPTOELECTRONICS CORPORATION | 2001-09-11 | — | — | US | claimed |
| US-6198569-B1 | Multiple window dense wavelength divison multiplexed communications link with optical amplification and dispersion compensation | MOLECULAR OPTOELECTRONICS CORPORATION | 2001-03-06 | — | — | US | claimed |
| WO-1999043058-A1 | FIBER OPTIC LASERS EMPLOYING FIBER OPTIC AMPLIFIERS | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-08-26 | — | — | WO | claimed |
| WO-1999043121-A2 | COMMUNICATIONS LINK OPTICAL AMPLIFICATION AND DISPERSION COMPENSATION | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-08-26 | — | — | WO | claimed |
| US-5815309-A | Optical amplifier and process for amplifying an optical signal propagating in a fiber optic | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1998-09-29 | — | — | US | claimed |
| WO-1998032048-A1 | OPTICAL WAVEGUIDE AMPLIFIER | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1998-07-23 | — | — | WO | claimed |
| US-5396362-A | High resolution micromachining of organic crystals and optical modulators formed thereby | GENERAL ELECTRIC COMPANY (US) | 1995-03-07 | — | — | US | claimed |
| US-6289027-B1 | Fiber optic lasers employing fiber optic amplifiers | MOLECULAR OPTOELECTRONICS CORPORATION | 2001-09-11 | — | — | US | disclosed |
| US-6198569-B1 | Multiple window dense wavelength divison multiplexed communications link with optical amplification and dispersion compensation | MOLECULAR OPTOELECTRONICS CORPORATION | 2001-03-06 | — | — | US | disclosed |
| US-6052220-A | Optical amplifier and process for amplifying an optical signal propagating in a fiber optic employing an overlay waveguide and stimulated emission | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 2000-04-18 | — | — | US | disclosed |
| WO-1999043057-A1 | OPTICAL AMPLIFIER AND PROCESS FOR AMPLIFYING AN OPTICAL SIGNAL PROPAGATING IN A FIBER OPTIC EMPLOYING AN OVERLAY WAVEGUIDE AND STIMULATED EMISSION | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-08-26 | — | — | WO | disclosed |
| WO-1999043058-A1 | FIBER OPTIC LASERS EMPLOYING FIBER OPTIC AMPLIFIERS | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-08-26 | — | — | WO | disclosed |
| WO-1999043121-A2 | COMMUNICATIONS LINK OPTICAL AMPLIFICATION AND DISPERSION COMPENSATION | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-08-26 | — | — | WO | disclosed |
| EP-0914698-A1 | OPTICAL WAVEGUIDE AMPLIFIER | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5815309-A | Optical amplifier and process for amplifying an optical signal propagating in a fiber optic | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1998-09-29 | — | — | US | disclosed |
| WO-1998032048-A1 | OPTICAL WAVEGUIDE AMPLIFIER | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1998-07-23 | — | — | WO | disclosed |
| WO-1998032199-A1 | OPTICAL WAVEGUIDE AMPLIFIER | MOLECULAR OPTOELECTRONICS CORPORATION (US) | 1998-07-23 | — | — | WO | disclosed |
| US-5396362-A | High resolution micromachining of organic crystals and optical modulators formed thereby | GENERAL ELECTRIC COMPANY (US) | 1995-03-07 | — | — | US | disclosed |
| US-5396362-A | High resolution micromachining of organic crystals and optical modulators formed thereby | GENERAL ELECTRIC COMPANY (US) | 1995-03-07 | — | — | US | disclosed |