Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 6/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8385319 | 0.91 | NAMPT (0.47) | NAMPTEPHX2HTTL3MBTL1TMPRSS2 | |
| SCHEMBL7909721 | 0.91 | POLB (0.46) | GAAITGB3ITGA2BNAMPTITGA2 | |
| SCHEMBL7913448 | 0.90 | GAA (0.45) | GAANAMPTEPHX2KMT2ASMYD3 | |
| SCHEMBL7900164 | 0.87 | MEN1 (0.50) | GAAITGB3ITGA2BITGA2EPHX2 | |
| SCHEMBL8386581 | 0.87 | FAAH (0.44) | HTTL3MBTL1TMPRSS2SMN1; SMN2MEN1 | |
| SCHEMBL7909446 | 0.86 | SMN1; SMN2 (0.49) | GAAITGB3ITGA2BITGA2EPHX2 | |
| SCHEMBL7900157 | 0.86 | ITGB3 (0.51) | GAAITGB3ITGA2BNAMPTITGA2 | |
| SCHEMBL8381689 | 0.85 | EPHX2 (0.53) | ITGB3ITGA2BNAMPTEPHX2HTT | |
| SCHEMBL8386238 | 0.84 | HTT (0.43) | NAMPTEPHX2HTTL3MBTL1SMN1; SMN2 | |
| SCHEMBL9337540 | 0.84 | GAA (0.53) | GAAITGB3ITGA2BITGA2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0608759-B1 | Piperazine derivatives | MERCK PATENT GMBH (DE) | 2001-08-22 | — | — | EP | disclosed |
| US-5908843-A | Piperazine compounds as fibrinogen inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1999-06-01 | — | — | US | disclosed |
| EP-0608759-A2 | Piperazinderivatives | MERCK PATENT GmbH (DE) | 1994-08-03 | — | — | EP | disclosed |