Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4508419 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4486230 | 0.83 | ALDH1A1 (0.47) | ALDH1A1ATMTP53L3MBTL1OPRL1 | |
| SCHEMBL13560163 | 0.77 | ALDH1A1 (0.50) | ALDH1A1ATMTP53L3MBTL1 | |
| SCHEMBL13560165 | 0.76 | ALDH1A1 (0.41) | ALDH1A1ATMTP53L3MBTL1 | |
| SCHEMBL30396227 | 0.75 | ALDH1A1 (0.39) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27539109 | 0.75 | SAT1 (0.40) | ALDH1A1LMNAGNAI3GNAO1GNAI1 | |
| SCHEMBL5255592 | 0.75 | LMNA (0.68) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL18985998 | 0.73 | ALDH1A1 (0.38) | ALDH1A1LMNATP53MAPT | |
| SCHEMBL13598984 | 0.72 | ALDH1A1 (0.53) | ALDH1A1ATMLMNAGNAI3GNAO1 | |
| SCHEMBL29252957 | 0.72 | GNAI3 (0.46) | ALDH1A1ATMHRH3GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194438-B1 | ANTITUMOR AGENTS; ANTICANCER AGENTS; FARNESYL-PROTEIN TRANSFERASE INHIBITOR | PFIZER INC. | 2001-02-27 | — | — | US | disclosed |
| EP-1006113-A1 | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth | Pfizer Products Inc. (US) | 2000-06-07 | — | — | EP | disclosed |