Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSB | P07858 | 3/20 | 0.35 |
| ▸ | CTSH | P09668 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7910227 | 1.00 | CTSK (0.38) | CTSKSMN1; SMN2CTSLCTSBCTSH | |
| SCHEMBL7897574 | 0.84 | CTSK (0.37) | CTSKCTSLCTSBCTSHKMT2A | |
| SCHEMBL21402585 | 0.77 | CTSK (0.40) | CTSKCTSLCTSBCTSH | |
| SCHEMBL20354169 | 0.76 | KDM4E (0.42) | — | |
| SCHEMBL7905711 | 0.76 | MAPK1 (0.42) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL7905716 | 0.76 | MAPK1 (0.42) | CTSKCTSLCTSBCTSHMEN1 | |
| SCHEMBL7907019 | 0.76 | HSD17B10 (0.45) | KMT2A | |
| SCHEMBL20028721 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2A | |
| SCHEMBL21941843 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2 | |
| SCHEMBL20028734 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204293-B1 | INHIBITING POST-TRANSLATIONAL MODIFICATION OF THE ONCOGENIC RAS PROTEIN BY PROTEIN FARNESYLTRANSFERASE, PROTEIN GERANYLGERANYLTRANSFERASE, OR BOTH | UNIVERSITY OF PITTSBURGH | 2001-03-20 | — | — | US | disclosed |
| WO-1998050031-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |