Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ACHE | P22303 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902974 | 0.92 | KDM4E (0.50) | KDM4EALDH1A1ALOX15RAB9ANPC1 | |
| SCHEMBL7913304 | 0.78 | ACHE (0.42) | KDM4EALDH1A1RAB9ANPC1CASP3 | |
| SCHEMBL2301745 | 0.74 | KDM4E (0.77) | KDM4EALDH1A1ALOX15HSD17B10TSHR | |
| SCHEMBL7902917 | 0.74 | ACHE (0.49) | KDM4EALDH1A1ALOX15RAB9ANPC1 | |
| SCHEMBL7913070 | 0.73 | KDM4E (0.75) | KDM4EALDH1A1ALOX15RAB9ANPC1 | |
| SCHEMBL7916322 | 0.73 | SLC9A1 (0.33) | KDM4E | |
| SCHEMBL7902779 | 0.72 | KDM4E (0.73) | KDM4EALDH1A1ALOX15RAB9ANPC1 | |
| SCHEMBL7903030 | 0.72 | KDM4E (0.73) | KDM4EALDH1A1ALOX15RAB9ANPC1 | |
| SCHEMBL23394674 | 0.71 | — | — | |
| SCHEMBL14163994 | 0.69 | KDM4E (0.51) | KDM4EALDH1A1ALOX15RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |