Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916616 | 0.85 | PDE4D (0.48) | PDE4DKMT2ARORCMEN1PRKD3 | |
| SCHEMBL7913253 | 0.85 | MAOB (0.34) | ALDH1A1SMN1; SMN2PDE4BCYP3A4CYP2C19 | |
| SCHEMBL7914652 | 0.82 | DYRK3 (0.37) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL7902852 | 0.80 | NPC1 (0.34) | KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL7912990 | 0.79 | PARP1 (0.37) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL7913078 | 0.79 | DYRK3 (0.37) | — | |
| SCHEMBL7917981 | 0.79 | DYRK3 (0.35) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL7929296 | 0.79 | DYRK3 (0.49) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7911686 | 0.78 | PGR (0.34) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7902988 | 0.77 | GRIN1 (0.32) | PDE4DSMN1; SMN2CYP3A4CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |