Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK3 | O43781 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 5/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913078 | 0.92 | DYRK3 (0.37) | DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL7929296 | 0.91 | DYRK3 (0.49) | DYRK3DYRK1ADYRK2DYRK1BALDH1A1 | |
| SCHEMBL7917981 | 0.91 | DYRK3 (0.35) | DYRK3DYRK1ADYRK2DYRK1BALDH1A1 | |
| SCHEMBL7902852 | 0.87 | NPC1 (0.34) | DYRK3DYRK1ADYRK2DYRK1BKMT2A | |
| SCHEMBL7912990 | 0.86 | PARP1 (0.37) | DYRK3DYRK1ADYRK2DYRK1BALDH1A1 | |
| SCHEMBL7902988 | 0.84 | GRIN1 (0.32) | RAB9A | |
| SCHEMBL7915334 | 0.84 | DHFR (0.32) | RAB9A | |
| SCHEMBL7902845 | 0.83 | PIM1 (0.31) | — | |
| SCHEMBL7916997 | 0.81 | JAK2 (0.35) | DYRK3DYRK1ADYRK2DYRK1BALDH1A1 | |
| SCHEMBL7915330 | 0.79 | MEN1 (0.36) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |