Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 7/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.32 |
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | FLT1 | P17948 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.32 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912990 | 0.91 | PARP1 (0.37) | KMT2AGRM5HIF1AHDAC1HDAC6 | |
| SCHEMBL7914652 | 0.87 | DYRK3 (0.37) | RAB9AKMT2AGRM5HDAC1HDAC6 | |
| SCHEMBL7902988 | 0.86 | GRIN1 (0.32) | NPC1RAB9ASMN1; SMN2CNR2GRIN1 | |
| SCHEMBL7915334 | 0.86 | DHFR (0.32) | NPC1RAB9ASMN1; SMN2STK4STK3 | |
| SCHEMBL7902845 | 0.85 | PIM1 (0.31) | CNR2 | |
| SCHEMBL7913078 | 0.84 | DYRK3 (0.37) | DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL7916997 | 0.83 | JAK2 (0.35) | NPC1RAB9ASMN1; SMN2KMT2ADYRK3 | |
| SCHEMBL7929296 | 0.83 | DYRK3 (0.49) | SMN1; SMN2DYRK3DYRK1ADYRK2DYRK1B | |
| SCHEMBL7917981 | 0.83 | DYRK3 (0.35) | POLBRAB9AKMT2ADYRK3DYRK1A | |
| SCHEMBL7913253 | 0.81 | MAOB (0.34) | SMN1; SMN2STK4STK3LRRK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |