Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7913175 | 0.85 | MAOB (0.33) | ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL7911295 | 0.85 | PDE4D (0.48) | PDE4DRORCKMT2AL3MBTL1MEN1 | |
| SCHEMBL7920535 | 0.79 | DHFR (0.33) | — | |
| SCHEMBL7915330 | 0.79 | MEN1 (0.36) | KMT2AMEN1 | |
| SCHEMBL7902850 | 0.79 | PGR (0.33) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7911681 | 0.77 | MAPT (0.36) | KMT2AMEN1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7930844 | 0.77 | PGR (0.33) | KMT2AMEN1ALDH1A1MAPTTP53 | |
| SCHEMBL7911301 | 0.73 | NLRP3 (0.35) | KMT2AL3MBTL1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7902855 | 0.73 | ALDH1A1 (0.43) | KMT2AL3MBTL1MEN1ALDH1A1HPGD | |
| SCHEMBL7913291 | 0.72 | ALOX5 (0.42) | PDE4DKMT2AL3MBTL1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059838-A2 | PDE4 INHIBITORS SELECTIVE FOR THE LONG FORM OF PDE4 FOR TREATING INFLAMMATION AND AVOIDING SIDE EFFECTS | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010059836-A1 | SUBSTITUTED AZA-BRIDGED BICYCLICS FOR CARDIOVASCULAR AND CNS DISEASE | DECODE GENETICS EHF (IS) | 2010-05-27 | — | — | WO | disclosed |