Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KIF5B | P33176 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.40 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7904610 | 0.88 | THRB (0.55) | THRBMAPTGAAKDRALDH1A1 | |
| SCHEMBL7913358 | 0.86 | THRB (0.49) | THRBMAPTGAAKDRALDH1A1 | |
| SCHEMBL7913378 | 0.83 | MAPT (0.55) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL7918619 | 0.82 | THRB (0.69) | THRBMAPTGAAKDRALDH1A1 | |
| SCHEMBL7915059 | 0.81 | NPSR1 (0.52) | THRBMAPTGAAKDRRET | |
| SCHEMBL7913339 | 0.81 | THRB (0.62) | THRBMAPTGAAKDRALDH1A1 | |
| SCHEMBL7918649 | 0.80 | MAPT (0.54) | MAPTGAAALDH1A1KDM4ELMNA | |
| SCHEMBL7915119 | 0.79 | MAPT (0.43) | MAPTGAAKDRALDH1A1KDM4E | |
| SCHEMBL7904829 | 0.76 | THRB (0.66) | THRBMAPTGAAKDRALDH1A1 | |
| SCHEMBL7914922 | 0.76 | MAPT (0.58) | MAPTKDRALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207666-B1 | TREATING PRECANCEROUS LESIONS BY ADMINISTERING 4-PHENYLPHTHALAZINE DERIVATIVE | CELL PATHWAYS, INC. | 2001-03-27 | — | — | US | disclosed |