Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 2/20 | 0.38 |
| ▸ | PRKACG | P22612 | 2/20 | 0.38 |
| ▸ | PRKACB | P22694 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | NOS2 | P35228 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19139283 | 0.79 | NOS3 (0.34) | NOS3NOS2F12PLAUNCF1 | |
| SCHEMBL27427296 | 0.78 | PRKACA (0.46) | PRKACAPRKACGPRKACBLRRK2NOS3 | |
| SCHEMBL15741185 | 0.75 | LRRK2 (0.40) | PRKACAPRKACGPRKACBLRRK2KDM4E | |
| SCHEMBL31622333 | 0.75 | LRRK2 (0.40) | PRKACAPRKACGPRKACBLRRK2KDM4E | |
| SCHEMBL1261198 | 0.75 | NOS2 (0.54) | PRKACAPRKACGPRKACBLRRK2NOS3 | |
| SCHEMBL22980341 | 0.75 | PRKACA (0.38) | PRKACAPRKACGPRKACBLRRK2NOS3 | |
| SCHEMBL565899 | 0.75 | HTT (0.41) | PRKACAPRKACGPRKACBLRRK2NOS3 | |
| SCHEMBL30679309 | 0.71 | PRKACA (0.36) | PRKACAPRKACGPRKACBLRRK2NOS3 | |
| SCHEMBL564697 | 0.71 | ALDH1A1 (0.53) | PRKACAPRKACGPRKACBKDM4EMEN1 | |
| SCHEMBL30731660 | 0.71 | KDM4E (0.41) | PRKACAPRKACGPRKACBLRRK2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010060589-A1 | INDOLE AND BENZOXAZINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-06-03 | — | — | WO | disclosed |