Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.32 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL820387 | 0.92 | NPC1 (0.35) | NPC1RAB9APNMTSRD5A2 | |
| Hydrochloric Acid SCHEMBL7913311 | 0.90 | NPC1 (0.33) | NPC1RAB9APNMTSRD5A2 | |
| Hydrochloric Acid SCHEMBL719838 | 0.83 | NPC1 (0.40) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL7918192 | 0.82 | NPC1 (0.37) | NPC1RAB9APNMTSRD5A2 | |
| Hydrochloric Acid SCHEMBL818262 | 0.81 | NPC1 (0.36) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL820366 | 0.81 | PNMT (0.36) | NPC1RAB9APNMT | |
| SCHEMBL8390466 | 0.80 | NPC1 (0.39) | NPC1RAB9APNMT | |
| Hydrochloric Acid SCHEMBL714669 | 0.80 | — | — | |
| Hydrochloric Acid SCHEMBL715154 | 0.79 | HPRT1 (0.30) | — | |
| Hydrochloric Acid SCHEMBL715566 | 0.78 | ACHE (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207774-B1 | COPOLYMERIZATION OF ETHYLENE WITH AN .ALPHA.-OLEFIN HAVING THREE OR MORE CARBONS BY USE OF AN OLEFIN POLYMERIZATION CATALYST CONTAINING A METALLOCENE COMPOUND, AN IONIZING IONIC COMPOUD, AND AN ORGANOALUMINUM COMPOUNDTHE METALLO | TOSOH CORPORATION (JP) | 2001-03-27 | — | — | US | disclosed |
| EP-0612769-B1 | Process for producing ethylene alpha-olefin copolymer | TOSOH CORP (JP) | 1997-11-12 | — | — | EP | disclosed |
| EP-0612769-A1 | Process for producing ethylene alpha-olefin copolymer | TOSOH CORPORATION (JP) | 1994-08-31 | — | — | EP | disclosed |