Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Lindane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentachlorophenol SCHEMBL164440 | 0.91 | TSHR (0.56) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Pentachlorophenol SCHEMBL9501530 | 0.84 | CYP1A2 (0.48) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Pentachlorophenol SCHEMBL18039457 | 0.84 | CYP1A2 (0.48) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Pentachlorophenol SCHEMBL9362639 | 0.84 | CYP1A2 (0.48) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Pentachlorophenol SCHEMBL10591497 | 0.82 | CYP1A2 (0.52) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Sorbitol SCHEMBL2688276 | 0.81 | LMNA (0.55) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Mannitol SCHEMBL11230894 | 0.81 | LMNA (0.55) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Pentachlorophenol SCHEMBL11235831 | 0.81 | TSHR (0.50) | CYP1A2CYP2C9TSHRHIF1AHPGD | |
| Lindane SCHEMBL1532717 | 0.80 | LMNA (0.47) | LMNAALDH1A1CYP3A4L3MBTL1TDP1 | |
| Lindane SCHEMBL4005859 | 0.80 | TSHR (0.71) | CYP1A2CYP2C9TSHRHIF1AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019078051-A1 | POLYIMIDE FILM, POLYIMIDE FILM PRODUCTION METHOD, LAMINATE, SURFACE MATERIAL FOR DISPLAY, TOUCH PANEL MEMBER, LIQUID CRYSTAL DISPLAY DEVICE, AND ORGANIC ELECTROLUMINESCENCE DISPLAY DEVICE | 大日本印刷株式会社 | 2019-04-25 | — | — | WO | disclosed |
| US-6235394-B1 | Heat-expandable microcapsules, process for producing the same, and method of utilizing the same | MATSUMOTO YUSHI-SEIYAKU CO., LTD. (JP) | 2001-05-22 | — | — | US | disclosed |