Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.34 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15732095 | 0.85 | KCNE1 (0.38) | TRPV1LMNAHTTTSHRSMN1; SMN2 | |
| SCHEMBL24090503 | 0.83 | TRPV1 (0.37) | TRPV1LMNAHTTTSHRSMN1; SMN2 | |
| SCHEMBL10651226 | 0.81 | TRPV1 (0.38) | HTR2ATRPV1HTR2CHTR2BKMT2A | |
| SCHEMBL10407553 | 0.81 | HTT (0.40) | TRPV1LMNAHTTSMN1; SMN2KCNE1 | |
| SCHEMBL10407835 | 0.81 | TRPV1 (0.35) | TRPV1LMNAHTTTSHRSMN1; SMN2 | |
| SCHEMBL10653035 | 0.80 | KCNE1 (0.36) | HTR2ALMNAHTTHTR2CHTR2B | |
| SCHEMBL10650405 | 0.80 | HTR2C (0.43) | HTR2ATRPV1LMNAHTR2CHTR2B | |
| SCHEMBL17061216 | 0.78 | PTGDR2 (0.44) | TRPV1LMNASMN1; SMN2 | |
| SCHEMBL7909660 | 0.78 | TRPV1 (0.30) | TRPV1 | |
| SCHEMBL1237664 | 0.77 | TRPV1 (0.37) | TRPV1LMNAHTTHTR2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6177449-B1 | CARDIOVASCULAR DISORDERS; ANTIULCER AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-01-23 | — | — | US | disclosed |
| EP-0157267-B1 | SUBSTITUTED BENZOPYRANS, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1988-11-23 | — | — | EP | disclosed |
| US-4659737-A | Substituted aminomethyl benzopyrans having anti-hypertensive activities | BAYER AKTIENGESELLSCHAFT (DE) | 1987-04-21 | — | — | US | disclosed |
| EP-0114374-B1 | SUBSTITUTED 4-AMINOMETHYLENE CHROMANS OR CHROMENES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN MEDICINES | BAYER AG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4563458-A | CIRCULATORY SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1986-01-07 | — | — | US | disclosed |
| EP-0157267-A2 | Substituted benzopyrans, process for their preparation and their use in medicines | BAYER AG (DE) | 1985-10-09 | — | — | EP | disclosed |
| EP-0114374-A1 | Substituted 4-aminomethylene chromans or chromenes, process for their preparation and their use in medicines | BAYER AG (DE) | 1984-08-01 | — | — | EP | disclosed |