SCHEMBL7914353

SCHEMBL7914353

N#Cc1ccccc1[C@@H](Cl)CCC(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 3/20 0.40
L3MBTL1 Q9Y468 2/20 0.40
ALDH1A1 P00352 3/20 0.39
TSHR P16473 2/20 0.39
CYP2D6 P10635 2/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
CPA3 P15088 1/20 0.38
MME P08473 1/20 0.38
AKR1B1 P15121 1/20 0.37
STAT3 P40763 1/20 0.36
GAA P10253 2/20 0.36
KDM4E B2RXH2 2/20 0.36
CCR1 P32246 1/20 0.35
TP53 P04637 1/20 0.35
GLA P06280 1/20 0.35
POLB P06746 1/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.35
ALOX12 P18054 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7914350 1.00 FFAR1 (0.40) FFAR1L3MBTL1ALDH1A1TSHRCYP2D6
SCHEMBL7908812 0.76 HTT (0.43) FFAR1ALDH1A1TSHRCYP2D6CYP1A2
SCHEMBL7911091 0.76 ALDH1A1 (0.42) ALDH1A1TSHRCYP2D6CYP1A2CYP2C19
SCHEMBL7907656 0.76 ALDH1A1 (0.42) ALDH1A1TSHRCYP2D6CYP1A2CYP2C19
SCHEMBL7907662 0.76 ALDH1A1 (0.42) ALDH1A1TSHRCYP2D6CYP1A2CYP2C19
SCHEMBL7908816 0.76 HTT (0.43) FFAR1ALDH1A1TSHRCYP2D6CYP1A2
SCHEMBL20853408 0.75 L3MBTL1 (0.45) L3MBTL1ALDH1A1TSHRSTAT3GAA
SCHEMBL11830832 0.74 XDH (0.42) FFAR1MMEAKR1B1
SCHEMBL1132531 0.72 CYP2D6 (0.48) FFAR1ALDH1A1TSHRCYP2D6CYP1A2
SCHEMBL7910713 0.72 CYP2D6 (0.48) FFAR1ALDH1A1TSHRCYP2D6CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211234-B1 BENZONITRILE COMPOUNDS WITH ETHER AND SULFIDE GROUPS WITH CARBOXY ACID RHONE-POULENC RORER LIMITED (GB) 2001-04-03 US disclosed
EP-0728128-B1 SUBSTITUTED PHENYL COMPOUNDS RHONE POULENC RORER LTD (GB) 1998-09-16 EP disclosed
EP-0728128-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1996-08-28 EP disclosed
WO-1995013262-A1 SUBSTITUTED PHENYL COMPOUNDS RHONE-POULENC RORER LIMITED (GB) 1995-05-18 WO disclosed