Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6592174 | 0.88 | PDE5A (0.58) | PDE5AMAPTTDP1KMT2A | |
| SCHEMBL7914801 | 0.85 | PDE5A (0.55) | PDE5A | |
| SCHEMBL6597884 | 0.83 | PDE5A (0.80) | PDE5A | |
| SCHEMBL7904428 | 0.78 | PDE5A (0.54) | PDE5A | |
| SCHEMBL6594486 | 0.77 | PDE5A (0.63) | PDE5AMAPTKMT2A | |
| SCHEMBL6597081 | 0.76 | PDE4A (0.57) | PDE5AMAPTKMT2A | |
| SCHEMBL5598718 | 0.76 | PDE4A (0.57) | PDE5ATDP1 | |
| Hydrochloric Acid SCHEMBL6606090 | 0.75 | PDE5A (0.48) | PDE5AMAPTKMT2A | |
| SCHEMBL7914746 | 0.74 | PDE4A (0.53) | PDE5A | |
| SCHEMBL8620057 | 0.74 | PDE5A (0.71) | PDE5AMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6218392-B1 | FOR THERAPY AND PROPHYLAXIS OF ISCHEMIC HEART DISEASES SUCH AS ANGINA PECTORIS, MYOCARDIAL INFARCT AND CHRONIC AND ACUTE CARDIAC FAILURE, PULMONARY HYPERTENSION, ARTERIOSCLEROSIS AND BRONCHIAL ASTHMA | EISAI CO., LTD. (JP) | 2001-04-17 | — | — | US | disclosed |
| US-5849741-A | Fused pyridazine compounds | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |