Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 9/20 | 0.71 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7911677 | 0.83 | PDE5A (1.00) | PDE5AMAPTKMT2AMEN1CRHBP | |
| SCHEMBL6594403 | 0.79 | PDE5A (1.00) | PDE5AMAPTKMT2AMEN1CRHBP | |
| SCHEMBL7914801 | 0.77 | PDE5A (0.55) | PDE5A | |
| SCHEMBL7918154 | 0.75 | PDE5A (0.92) | PDE5A | |
| SCHEMBL7914747 | 0.74 | PDE5A (0.55) | PDE5AMAPTKMT2A | |
| SCHEMBL7262122 | 0.73 | MAPT (0.41) | PDE5AMAPTKMT2AMEN1CRHBP | |
| SCHEMBL6597241 | 0.71 | PDE5A (1.00) | PDE5A | |
| SCHEMBL5598718 | 0.71 | PDE4A (0.57) | PDE5A | |
| SCHEMBL1091355 | 0.68 | HSD17B10 (0.52) | PDE5AMAPTKMT2AMEN1 | |
| SCHEMBL29595163 | 0.68 | HSD17B10 (0.52) | PDE5AMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719303-A | USEFUL FOR MEDICALLY TREATING HYPERLIPEMIA | EISAI CO., LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0688325-A1 | PHOSPHONIC ACID DERIVATIVES | Eisai Co., Ltd. (JP) | 1995-12-27 | — | — | EP | disclosed |
| WO-1994020508-A1 | PHOSPHONIC ACID DERIVATIVES | EISAI CO., LTD. (JP) | 1994-09-15 | — | — | WO | disclosed |