Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOX1 | Q06278 | 1/20 | 0.58 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8484070 | 0.89 | AOX1 (0.51) | AOX1ACHEMEN1KMT2ANPSR1 | |
| SCHEMBL28623371 | 0.83 | ACHE (0.50) | AOX1ACHEMEN1KMT2ANPSR1 | |
| SCHEMBL2521329 | 0.83 | AOX1 (0.60) | AOX1ACHEMEN1KMT2ANPSR1 | |
| SCHEMBL4247405 | 0.83 | TSHR (0.55) | AOX1MEN1KMT2AHPGDALDH1A1 | |
| SCHEMBL8412588 | 0.83 | MEN1 (0.49) | AOX1MEN1KMT2AHIF1A | |
| SCHEMBL779739 | 0.82 | AOX1 (0.64) | AOX1ACHEMEN1KMT2ANPSR1 | |
| SCHEMBL28068172 | 0.81 | AOX1 (0.62) | AOX1ACHEMEN1KMT2ANPSR1 | |
| SCHEMBL9761734 | 0.81 | MEN1 (0.51) | AOX1MEN1KMT2AHPGDL3MBTL1 | |
| SCHEMBL8487370 | 0.80 | CETP (0.49) | MEN1KMT2A | |
| SCHEMBL2515116 | 0.80 | AOX1 (0.66) | AOX1ACHEMEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6221865-B1 | INHIBITORS OF PROTEIN FARNESYLTRANSFERASE AND PROTEIN GERANYLGERANYLTRANSFERASE. | UNIVERSITY OF PITTSBURGH | 2001-04-24 | — | — | US | disclosed |
| WO-1998050030-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-11-12 | — | — | WO | disclosed |