Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 2/20 | 0.31 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.30 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.30 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7919038 | 0.86 | PLAU (0.36) | PLAUAKR1C3AKR1C2NPC1RAB9A | |
| SCHEMBL7916827 | 0.85 | PLAU (0.33) | PLAUAKR1C3AKR1C2 | |
| SCHEMBL16502539 | 0.85 | NPC1 (0.45) | PLAUNPC1RAB9AMAPK14 | |
| SCHEMBL7917796 | 0.84 | PLAU (0.35) | PLAUAKR1C3AKR1C2RAB9AF2 | |
| SCHEMBL7908906 | 0.81 | PLAU (0.34) | PLAURAB9AF2PLGPLAT | |
| SCHEMBL7920004 | 0.80 | PLAU (0.34) | PLAURAB9AF2PLGPLAT | |
| SCHEMBL7918428 | 0.79 | SLC6A4 (0.40) | PLAUNPC1RAB9AF2PLG | |
| SCHEMBL16502546 | 0.79 | PLA2G2D (0.49) | AKR1C3AKR1C2 | |
| SCHEMBL7913827 | 0.79 | ALOX15 (0.36) | PLAUNPC1RAB9ACYP17A1CYP11B1 | |
| SCHEMBL7915719 | 0.78 | RAB9A (0.40) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |