Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | F2 | P00734 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAT | P00750 | 1/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7908906 | 0.91 | PLAU (0.34) | PLAUMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7916775 | 0.86 | PLAU (0.32) | PLAU | |
| SCHEMBL7906753 | 0.83 | MAPT (0.36) | PLAUMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7917796 | 0.82 | PLAU (0.35) | PLAUMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7916572 | 0.81 | HSD17B14 (0.37) | PLAUMEN1KMT2AMAPT | |
| SCHEMBL7919038 | 0.81 | PLAU (0.36) | PLAUMEN1KMT2AMAPTRAB9A | |
| SCHEMBL7911006 | 0.80 | HDAC8 (0.40) | PLAUMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7916552 | 0.80 | PLAU (0.34) | PLAURAB9AF2PLGPLAT | |
| SCHEMBL7915957 | 0.79 | KDM4E (0.39) | PLAUALDH1A1F2PLGPLAT | |
| SCHEMBL7918428 | 0.79 | SLC6A4 (0.40) | PLAUMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |