Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.31 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.31 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916827 | 0.90 | PLAU (0.33) | PLAUAKR1C3AKR1C2CASP3SENP7 | |
| SCHEMBL7919038 | 0.85 | PLAU (0.36) | PLAUAKR1C3AKR1C2F2PLG | |
| SCHEMBL7916552 | 0.84 | PLAU (0.34) | PLAUAKR1C3AKR1C2F2PLG | |
| SCHEMBL16502566 | 0.84 | NQO2 (0.44) | PLAUAKR1C3AKR1C2MEN1ALDH1A1 | |
| SCHEMBL7908906 | 0.83 | PLAU (0.34) | PLAUF2PLGPLATKLK1 | |
| SCHEMBL7921816 | 0.82 | CA1 (0.35) | PLAUMEN1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL7920004 | 0.82 | PLAU (0.34) | PLAUF2PLGPLATKLK1 | |
| SCHEMBL7918428 | 0.81 | SLC6A4 (0.40) | PLAUF2PLGPLATKLK1 | |
| SCHEMBL7915719 | 0.80 | RAB9A (0.40) | CASP3MEN1ALDH1A1MAPTRAB9A | |
| SCHEMBL7915957 | 0.79 | KDM4E (0.39) | PLAUF2PLGPLATKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |