Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 5/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7916825 | 0.83 | ACHE (0.35) | NNMTACHEDRD2HTR2AHTR2B | |
| SCHEMBL7911218 | 0.81 | MAPT (0.31) | MAPT | |
| SCHEMBL27726461 | 0.77 | NNMT (0.55) | NNMTMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18779349 | 0.73 | ACHE (0.45) | NNMTACHEMAPTPOLBALDH1A1 | |
| SCHEMBL7903016 | 0.72 | ADRA2A (0.44) | NNMTMAPTSMN1; SMN2POLBPKM | |
| SCHEMBL7916798 | 0.72 | ADRA2A (0.44) | NNMTMAPTSMN1; SMN2POLBPKM | |
| SCHEMBL7912936 | 0.71 | ADRA2A (0.45) | NNMTDRD2HTR2AHTR2BMAPT | |
| SCHEMBL9192239 | 0.71 | MAPT (0.56) | MAPTSMN1; SMN2POLBBLMNR3C1 | |
| Dimethylamine SCHEMBL7911323 | 0.71 | ADRA2A (0.42) | NNMTMAPTSMN1; SMN2POLBPKM | |
| SCHEMBL7910325 | 0.71 | GRM5 (0.36) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6258829-B1 | ANTIARRTHMIA AGENTS AND CARDIOVASCULAR DISORDERS | TOA EIYO LTD. (JP) | 2001-07-10 | — | — | US | disclosed |
| EP-0972767-A1 | CYCLOALKA[b]PYRIDINE-3-CARBONYLGUANIDINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME, AND DRUGS CONTAINING THE SAME | TOA EIYO LTD. (JP) | 2000-01-19 | — | — | EP | disclosed |