Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B14 | Q9BPX1 | 3/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 11/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | PLG | P00747 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | KLK1 | P06870 | 1/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16502671 | 0.86 | KDM4E (0.44) | KDM4EALDH1A1HPGDPLAUTGFBR1 | |
| SCHEMBL16502696 | 0.81 | KDM4E (0.53) | KDM4EALDH1A1HPGDHSD17B14TGFBR1 | |
| SCHEMBL7919038 | 0.80 | PLAU (0.36) | KDM4EHSD17B14PLAUF2PLG | |
| SCHEMBL7920004 | 0.79 | PLAU (0.34) | ALDH1A1PLAUF2PLGPLAT | |
| SCHEMBL7917796 | 0.79 | PLAU (0.35) | ALDH1A1PLAUF2PLGPLAT | |
| SCHEMBL7914783 | 0.78 | GABRG2 (0.34) | KDM4EALDH1A1HPGDPLAU | |
| SCHEMBL7908906 | 0.78 | PLAU (0.34) | ALDH1A1PLAUF2PLGPLAT | |
| SCHEMBL7916552 | 0.77 | PLAU (0.34) | PLAUF2PLGPLATKLK1 | |
| SCHEMBL7916572 | 0.76 | HSD17B14 (0.37) | HSD17B14PLAU | |
| SCHEMBL7918428 | 0.76 | SLC6A4 (0.40) | KDM4EALDH1A1HPGDPLAUF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010090304-A1 | ACYLGUANIDINE DERIVATIVE | アステラス製薬株式会社 (JP) | 2010-08-12 | — | — | WO | disclosed |