Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616402 | 0.79 | ADRA2A (0.49) | HTR2A | |
| SCHEMBL7917837 | 0.78 | HTR1A (0.33) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL8556517 | 0.73 | SIGMAR1 (0.39) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL8554610 | 0.73 | SIGMAR1 (0.39) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL8651098 | 0.69 | ADRA2A (0.48) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL9583897 | 0.68 | SIGMAR1 (0.39) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL18517719 | 0.68 | HTR1A (0.43) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL7917935 | 0.68 | S1PR1 (0.40) | HTR2AHTR1AHTR1BHTR2CHTR7 | |
| SCHEMBL75539 | 0.66 | HTR2A (0.43) | HTR2AHTR2C | |
| SCHEMBL7922088 | 0.65 | CARM1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042475-A1 | SPIROAMINOOXAZOLINE ANALOGUES AS ALPHA2C ADRENERGIC RECEPTOR MODULATORS | SCHERING CORPORATION (US) | 2010-04-15 | — | — | WO | disclosed |