Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 8/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8615518 | 0.83 | ADRA1A (0.40) | ADRA2ADRD2DRD3 | |
| SCHEMBL14123572 | 0.80 | ADRA2A (0.52) | ADRA2ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL7918403 | 0.79 | HTR2A (0.31) | HTR2A | |
| SCHEMBL7917837 | 0.78 | HTR1A (0.33) | HTR2A | |
| SCHEMBL7913143 | 0.78 | HTR1A (0.33) | HTR2A | |
| SCHEMBL7910926 | 0.77 | ADRA2A (0.49) | ADRA2ADRD2DRD3CHRM2CHRM1 | |
| SCHEMBL8620656 | 0.75 | ADRA2A (0.48) | ADRA2ADRD2DRD3DRD4CHRM2 | |
| SCHEMBL9251629 | 0.74 | ADRA1A (0.32) | — | |
| SCHEMBL12789703 | 0.74 | ADRA2A (0.49) | ADRA2ADRD2DRD3HTR2ACHRM2 | |
| SCHEMBL4599810 | 0.74 | ADRA2A (0.47) | ADRA2ADRD2DRD3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635496-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-04-29 | — | — | EP | disclosed |
| US-5464859-A | Alpha adrenergic antagonist | ADIR ET COMPAGNIE (FR) | 1995-11-07 | — | — | US | disclosed |
| EP-0635496-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |